Evaluación comparativa de la actividad ansiolítica de los extractos de hojas y flores de Passiflora quadrangularis y Passiflora edulis en ratones Mus musculus por administracion oral.

Abstract

The Passilora edulis and Passiflora quadrangularis are species Little studied in the country with a great diversity, also known for its therapeutic properties, the most common is the anxiolytic, its content in flavonoids apigenin type, luteolin and isovitexin are being studied for evauating the anxiolytic effect. The aim of the research was to buy the anxiolytic activity of extracts and leaves and flowers of Passiflora edulis and Passiflora quadrangularis in mice (Mus musculus) in four models in vivo, elevated plus maze (EPM), open field test (OFT), light/dark room and muscle relaxant activity. The Clonazepam was used as a standard drug (0.05 mg/kg) and to evaluate the toxicity of the extracts was made using the technique of Artemia salina. The group had a higher toxicity by the method of Artemia salina was the metanol extract of flowers of Passiflora quadrangularis since its LC50 was less tan 10ppm while the insurance was the metanol extract of leaves of Passiflora quadrangularis a LC50 of 921.22ppm. In the EPM model the metanol exract of leaves of Passilora edulis increases the time spent in the open arms (p<0.05), and similary in the different test such as (OFT), light/dark room and muscle relaxant activity yield positive results before the anxiolytic activity in experimental animals. The exract from Passilora edulis leaves apparent presents the best effect. It is recommended that subsequent recommendations with different dose levels in order to define the best effect holds as it is recommended that the toxicity of the extracts managing high mice dose and then conduct clinical test to determine with greater certainty the potencial damage body.