Actividad Cicatrizante In Vivo de los Extractos Metanólicos de justicia Chlorostochya y Plectranthus Amboinicus en ratones diabéticos inducidos mediante Estreptozotocina

Abstract

The healing activity of m ethanol extracts of Plectranthus amboinicus and Justicia chlorostachya in the animal model laboratory mouse ( Mus musculus ) strain BALB/ c the previously diabetes was induced by administration of streptozotocin, was evaluated after applying a block design randomly to experimental treatment groups at the doses of 200 mg/kg and 400 mg/ kg of methanol extract per kilogram of animal, for each pl ant species were administered. A positive control and a negative control for discriminating progress of the healing process without the presence of active ingredients were used. The extracts were obtained by soxhlet extraction process from 50 grams of the dried aerial part of the plant species. A significant decrease in wound area macroscopically for the time stated in the experimental protocol was obtained results, showing the effectiveness of the treatments on the wounds of diabetic mice. This was tested using ANOVA followed by TUKEY test post being P. amboinicus extract the most effective from the statistical standpoint, made it became apparent that even existed since the crust total detachment of the end of treatment. However, can ’t neglect the effects o f other treatments, since exhibit a significant percentage of healing. In complement, the toxic effect of the extract of P. amboinicus at a dose of 2000 mg/ kg in a group established in the same experimental model was evaluated, the results were satisfactor y since there was no toxic effect, thereby which shows that the plant is safe to eat, especially if it is administered topically. Research yields new expectations in the study of natural products and improving the quality of life of diabetic patients.