Evaluación de la actividad antiinflamatoria de extractos de las hojas de caña agria (costus spicatus) en ratas (rattus norvegicus) con edemas inducidas por carragenina

Abstract

The present study aimed to evaluate the anti - inflammatory activity of extracts from the leaves of sour cane ( Costus spicatus ) in rats ( Rattus norvegicus ) with edema induced by carrageenan, it was carried out at the Vivarium of Sciences Faculty of Escuela Superior Politécnica de C himborazo, with the purpose to contribute with new alternatives to the treatment of inflammatory co nditions. To determine the safet y use of the plant, quality control testing of the plant and the ethanol extract were conducted to evaluate the anti - inflammatory activity of sour cane ( Costus spicatus ) for which 18 experimental animals ( Rattus norvegicus ) were used the same that were divided in a random way into 6 groups: GEP (P ositive experimental group: Naproxen Sodium plus carrageenan to 1%), G EN (N egative experimental group: carrageenan 1%), GEB (W hite experimental group: Vehicle Tween 80 to 1% plus distilled water); the groups treated with the different extracts were GE1 (Experimental group 1: ethanol extract 20% plus carrageenan to 1%), GE2 ( Experimental group 2 : ethanol extract 40% plus carrageenan to 1%), GE3 (Experimental group 3: ethanol extract 80% plus carrageenan to 1%). The route of administration used was oral, the vehicle used tween 80 to 1% and distilled water. Swelling volumes p roduced by the carrageenan on the plantar aponeurosis were measured from 0 to 6 hours, and data analysis was performed using ANOVA test and TUKEY with range of 95% of confidence. It was concluded that the plant extract to 80% presents an anti - inflammatory activity similar to Naproxen Sodium. The toxicological study showed that the plant is not damaged at the tissue level of the main pharmacokinetic organs involved (stomach, liver and kidney). From this research it is recommended to establish a specific dos e to produce a phytomedicine that facilitates its storage and administration.