Elaboración de un fitofármaco semisólido de acción adelgazante con diferentes dosis a base de alcachofa (Cynara cardunculus - var scolymus), jengibre (Zingiber officinale) y cáscara de naranja (Citrus ninensis) administrado a personas para comparar eficacia

Abstract

The research is the elaboration of a slimming gel based on Artichoke (Cynara cardunculus var scolymus), Ginger (Zingiber officinale) and Orange Peel (Citrus sinensis), carried out in the Laboratory of Phytochemistry, Bromatology and Instruments of the Faculty of Sciences of ESPOCH. The extracts were obtained by maceration and the active principles were identified by phytochemical screening and thin layer chromatography. Two concentrations were prepared, a minimum and a maximum to determine which is more effective. The thinning gel was prepared from Carbopol ultrez 21(1%), TEA (Triethanolamine) (3%), Dimethicone (2%), Methylparaben (1%), Distilled water (80%) and mixture of Natural Extracts (12%) obtaining a semi-solid phytopharmaceutical of yellow color, good smoothness to the touch and no presence of lumps, it is homogeneous with a viscosity of 5170. 3 centipois, extensibility of 3.8 cm and pH of 4.78. The microbiological analysis showed the absence of contaminating microorganisms, which means that the physical, chemical and microbiological characteristics comply with the established parameters. The slimming activity of the gel was carried out on volunteers in four groups, a positive control, a negative control, a group to which the minimum dose was applied and one to which the maximum dose was applied, of which the one that gave the best result was the maximum formulation for eliminating the highest percentage of body fat as well as that of the caffeine gel tested. It is recommended to carry out a long-term stability study by developing analytical methods to obtain data on the useful life time as well as a study to determine if at the end or suspension of the treatment there is a rebound effect.