Elaboración de Tabletas Adelgazantes a Partir de Tres Plantas Existentes en la Provincia de Chimborazo a Escala Piloto

Abstract

The elaboration of slimming tablets at pilot scale was carried out in the laboratories of phytochemistry, microbiology and phytomedicines pilot plant of the Faculty of Sciences, using the deductive scientific method. Extracts of chamomile (Matricaria recutita), garlic (Allium sativum), ginger (Zingiber officinale), 73% of dicalcium phosphate, 23% of micro crystalline cellulose, 3% of poly vinyl pyrrolidone, 1% of magnesium stearate, 10.9% and compressed by the wet granulation method in which all the components are mixed and sieved in mesh N°25 and compressed in the Stokes RBII tabletting machine. Tablets were obtained with the following quality specifications for the three batches for four months, they are white in color with beveled edges, aromatic odor, weight of 601.6; 601.1; 601mg; hardness 7.85; 7.80; 7.31 Kgf, a thickness of 9.03; 8.98; 9.05mm; friability of 0. 42; 0.43; 0.40%; disintegration of 1:43; 1:48; 1:40 min containing as active principles with a concentration of quercetin Rf 0.93; M0 of 0.0097mg , M4 of 0.0080; Alcine of 0.23; M0 of 0.0083mg ,M4 of 0.0055 mg; Gingerols Rf of 0.25; M0 of 0.0075mg ,M4 of 0.0025. All these data statistically analyzed by ANOVA test, showed that all the characteristics are similar for the three batches so that pilot batches of 10 kg can be elaborated, these characteristics were established according to the USP25, thesis of Falconí M, Barros K, the shelf life was established in two years by means of Poope's method. A stability study under normal conditions is recommended to verify the shelf life.