Actividad antimicótico del extracto etanólico de hojas de Chenopodium ambrosioides L. Frente a Candida albicans

Abstract

The present research aimed to determine in vitro antifungal activity of ethanolic extract of the leaves of Chenopodium ambrosioides L. against Candida albicans is experimental with a qualitative and quantitative approach. Once the price leaves were in good condition collected, they were dried and milled, and the maceration technique with 96% ethanol was carried out; the maceration was kept in a dry and cool place, away from light, for seven days. The parameters of the vegetable drug "paico" were established as the percentage of yield of 14.28% and the determination of total ash of 2.2%. The phytochemical screening carries out according to the reactions of coloration and precipitation obtained; it observes that in the ethanolic extract of leaves of Chenopodium ambrosioides L., there is the presence of flavonoids, saponins, triterpenes, and steroids. Using the Kirby Bauer method, the evaluation of the in vitro antifungal activity of ethanolic extract of paico leaves was carried out at concentrations of 25% reached 11.34 mm (sensitive); at a concentration of 75% reached 16.52 mm (intermediate); and 100% was 21.94 mm (resistant), on strains of Candida albicans, in which it is evident that the highest antifungal activity is the concentration of 100% that is capable of inhibiting antifungal growth. Finally, the antifungal strains under the study of the different concentrations were compared with the sensitivity discs fluconazole and miconazole; through this test, it was possible to establish the antifungal power of the ethanolic extract of paico. It concludes that the plant has excellent antifungal potential, which has yet to be studied. It recommends carrying out studies on the plant species to discover its possible antifungal compounds that may be able to combat Candida albicans.