Desarrollo, Control de Calidad y Comparación de una Tableta de Meloxicam con Tres Similares en el Mercado.

Abstract

"To develop a Meloxican tablet and compare their physical and chemical properties with three similar in the market is the objective proposed in this rescarch, it took place in the Quality Control and Production Department of Laboratory Nco-Farmaco in Ecuador, based in the city of Ambato.

The experimental method was used which comprisc quality control on raw materials, manufacturing procces and finished product, it was obtained values which are within specifcations. Unitary formula for the tablets is constituted by Meloxican as active ingredient, 3.2% PVP binder, diluents: com starch at 53%, 30% lactose and 7.5% starch 1500; talcum poder in 0.3% and the 0.5% magnesium stereate ; disintegrants: sodium starch glycolate in 0.25, so obtaining 280mg tablets by weight with 15 mg of active ingredient base don wet granulation, allowing it to met with all set quality parameters such as organoleptic characteristics , grain moisture 2.55%, 8.48 Kp hardness, average weight 276.38 mg, desintegration in 4028 minutes and friability of 0.15%, valuation of. 100,47 active ingredient, content uniformity 14.97 mg, 100.36% solution.

So it was found that the tablets prepared in Nco- Farmaco are of equal quality compared to the three Pharmaccutical laboratories mentioned, providing — good bioavailability, accuracy in dose, less volumen to be tolarated by the patients to ingest, complying with all the parameters required by Farmacopea.

Its recommended to carry out the accelerated stability study at a time of six months to check for altering the organoleptic characteristics and phisycal- chemical of the product."