Formulación y control de calidad de jabón líquido corporal antibacteriano a base de extractos de Melissa officinalis y Myrcianthes hallii

Abstract

The aim of this research was to formulate and elaborate an antibacterial body wash soap from hydroalcoholic extracts of Melissa officinalis and Myrcianthes hallii leaves. These plant species have various therapeutic properties, being the most promising one, the antibacterial activity; that is why they were considered for the preparation of the product. As part of the elaboration process, the quality control of the crude vegetable drug was carried out, and subsequently the content of secondary metabolites was qualitatively evaluated by means of phytochemical screening. Then, the hydroalcoholic extracts of M. officinalis and M. hallii leaves were obtained, and quality control was carried out together with the quantification of phenolic compounds and flavonoids. Twelve samples were formulated, considering the alcoholic degree variation of the extracts and raw materials, the physicochemical parameters (pH, density, foam level, viscosity, alkalinity) and organoleptic parameters were measured. The microbiological effectiveness analysis was performed by using a control disk, "Fox Disk" or oxacillin against the Staphylococcus aureus strain. Twenty surveys were also carried out to determine the acceptability of the product. According to the results obtained, formulation 9 presented an inhibition halo of 20 mm, optimal pH 7.18, viscosity 2258 mPa*S, density 1.0279, alkalinity 0.24 and acceptability 100%, being the organoleptic aspects, the ones preferred by consumers. Based on the results obtained, it was concluded that formulation 9 complies with all the limits established by the Ecuadorian Regulations as an ideal formula, therefore the product was harmless and safe for use on the skin. Stability tests are recommended to determine the useful lifetime and storage conditions of the product.